Project Description



Patients receiving prolonged invasive mechanical ventilation due to SARS-CoV-2 pneumonia appear to be exposed to increased risks of getting infections (tracheobronchitis or pneumonia). However, based on the limited data available, the incidence of hospital-acquired infections appears to be very low. This European project (39 centres, including 31 in France) involves 1,400 patients. Prospects for the prevention of the occurrence of serious forms in at-risk patients could be considered. It could also be considered to improve care for infections acquired while receiving mechanical ventilation (IAMV) in SARS-CoV-2 infected patients.


To determine the impact of SARS-CoV-2 infection on the incidence of IAMV, as compared to patients with influenza infection or no viral infection, occurring beyond the 48th hour of mechanical ventilation until extubation or on D-28 post intubation.

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1576 patients were included (568 in SARS-CoV-2, 482 in infuenza, and 526 in no viral infection groups). VALRTI incidence was signifcantly higher in SARS-CoV-2 patients (287, 50.5%), as compared to infuenza patients (146, 30.3%, adjusted sub hazard ratio (sHR) 1.60 (95% confdence interval (CI) 1.26 to 2.04)) or patients with no viral infec‑ tion (133, 25.3%, adjusted sHR 1.7 (95% CI 1.2 to 2.39)). Gram-negative bacilli were responsible for a large proportion
(82% to 89.7%) of VA-LRTI, mainly Pseudomonas aeruginosa, Enterobacter spp., and Klebsiella spp.

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