Project Description

physiopathologie

Summary:

Various studies show that obesity is associated with chronic systemic inflammation, contributing to the worsening of other inflammatory pathologies and suggesting a major impact for obesity-associated immune populations regarding the lung function. This project aims at analyzing circulating immune cells, adipose tissue, and liver to determine whether immune dysregulation, correlated with metabolic alterations, is responsible for the frequent worsening of COVID-19 pneumonia in obese individuals.

Objective:

The theory in this project is that pre-existing obesity-induced inflammation is added to or associated with COVID-19-induced inflammation through a quantitative or qualitative alteration in immune populations, resulting in pathology worsening.

Project initiators:

David Dombrowicz et François Pattou