During this new global pandemic related to COVID-19, it was noticed that 15% of patients affected with the disease develop acute respiratory distress syndrome (ARDS) and possibly multi-visceral failure requiring intensive care. One of the particularities of the latter is the development of fibrosis (rapid pulmonary alteration), with – in most cases – the massive presence of fibroblastic cell proliferation areas. The study of their role in the development of the disease could represent a key element in the short term to better understand COVID-19 and facilitate the maximisation of therapies to be proposed.
To accurately define the behaviour of cells called human primary lung fibroblasts (HLF) cultured in the presence of BAL (bronchoalveolar lavage) collected from COVID-19 patients with severe lung disease.
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