Project Description

physiopathologie

Summary:

During this new global pandemic related to COVID-19, it was noticed that 15% of patients affected with the disease develop acute respiratory distress syndrome (ARDS) and possibly multi-visceral failure requiring intensive care. One of the particularities of the latter is the development of fibrosis (rapid pulmonary alteration), with – in most cases – the massive presence of fibroblastic cell proliferation areas. The study of their role in the development of the disease could represent a key element in the short term to better understand COVID-19 and facilitate the maximisation of therapies to be proposed.

Objective:

To accurately define the behaviour of cells called human primary lung fibroblasts (HLF) cultured in the presence of BAL (bronchoalveolar lavage) collected from COVID-19 patients with severe lung disease.

Project initiator :

Silvia Speca