RESULTS

Since the beginning of the epidemic, the Lille Task Force institutions have been involved in a very large number of therapeutic and observational research projects.

In just a few weeks, it was possible to publish the initial results found in Lille, with a major impact on the understanding of the virus and the epidemic:

  • On 9 April 2020, an article published in “Obesity” shows that patients suffering from obesity are seven times more likely to be placed on a ventilator than patients with a regular weight.
  • On 23 April 2020, an article published in “Intensive Care Medicine” on histological lung analyses shows that pneumonia due to COVID-19 is not linked to alveolar exudate like in most cases of respiratory distress in intensive care but that it is characterized by intra-alveolar fibrin deposits, opening up prospects for the use of anti-inflammatory drugs.
  • On 24 April 2020, an article published in “Circulation” shows the high prevalence of pulmonary embolism cases, which increased more than twofold, among patients hospitalized for Covid-19.

To consolidate these initial preliminary results, the task force is coordinating and supporting 28 research projects on Covid-19. The results will be published in this section.

1576 patients were included (568 in SARS-CoV-2, 482 in infuenza, and 526 in no viral infection groups). VALRTI incidence was signifcantly higher in SARS-CoV-2 patients (287, 50.5%), as compared to infuenza patients (146,
30.3%, adjusted sub hazard ratio (sHR) 1.60 (95% confdence interval (CI) 1.26 to 2.04)) or patients with no viral infec‑
tion (133, 25.3%, adjusted sHR 1.7 (95% CI 1.2 to 2.39)). Gram-negative bacilli were responsible for a large proportion
(82% to 89.7%) of VA-LRTI, mainly Pseudomonas aeruginosa, Enterobacter spp., and Klebsiella spp.
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Prone positioning under VV-ECMO improves oxygenation in SARS-CoV-2-induced ARDS without compromising the safety of the patients.
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